7525-23-7

Basic information

• Product Name: BIS(4-METHOXYPHENYL)METHYL CHLORIDE
• Synonyms: BIS(4-METHOXYPHENYL)METHYL CHLORIDE
• CAS NO: 7525-23-7
• Molecular Formula: C₁₅H₁₅ClO₂
• Molecular Weight: 262.734
• Mol File: 7525-23-7.mol
• Article Data: 40

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BIS(4-METHOXYPHENYL)METHYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(4-METHOXYPHENYL)METHYL CHLORIDE(7525-23-7)
• EPA Substance Registry System: BIS(4-METHOXYPHENYL)METHYL CHLORIDE(7525-23-7)

Safety Data

• Hazardous Substances Data: 7525-23-7(Hazardous Substances Data)

Upstream product

• 728-87-0 4,4'-Dimethoxybenzhydrol 
• 46835-92-1 bis(p-methoxyphenyl)methyl cation 
• 885-77-8 4,4'-dimethylbenzhydrol 
• 615-93-0 2,5-Dichloro-1,4-benzoquinone 
• 726-18-1 4,4'-dianisylmethane 
• 42240-30-2 bis-(4-methoxyphenyl)methyl acetate 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 1393825-91-6 C₃₈H₃₉N₄O₂⁽¹⁺⁾*Cl^(1-) 
• 100-66-3 methoxybenzene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 116664-86-9 bis(4-methoxyphenyl)methyl 4-cyanophenyl ether 
• 90-96-0 bis(p-methoxyphenyl)methanone 

Downstream Products

• 102994-17-2 1-[bis(4-methoxyphenyl)methyl]-1H-imidazole 
• 154544-66-8 diethyl phosphonate 
• 144102-56-7 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-{3-[bis-(4-methoxy-phenyl)-methyl]-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 
• 75-77-4 chloro-trimethyl-silane 
• 102372-93-0 1-ethyl-3-(4,4'-dimethoxy-benzhydryloxy)-pyrrolidine 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 483365-52-2 di(p-methoxyphenyl)-methoxyethyl bromide 
• 2186-95-0 4,4′-dimethoxybenzhydryl methyl ether 
• 90481-27-9 (E)-2-{[Bis-(4-methoxy-phenyl)-methyl]-amino}-hept-3-enenitrile 
• 77604-34-3 [Bis-(4-methoxy-phenyl)-methyl]-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-amine 

Relevant articles and documents

Preparation method of bisacodyl

The present invention provides the preparation method shown in formula I., the preparation method of bisacodyl. The present invention provides a new method for the preparation of bisacodyl.

Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated 18F-trifluoromethylation procedure

Trifluoromethyl groups are widespread in medicinal chemistry, yet there are limited 18F-radiochemistry techniques available for the production of the complementary PET agents. Herein, we report the first radiosynthesis of the anticancer nucleoside analogue trifluridine, using a fully automated, clinically-applicable 18F-trifluoromethylation procedure. [18F]Trifluridine was obtained after two synthetic steps in 99%, and a molar activity of 0.4 GBq μmol-1 ± 0.05. Biodistribution and PET-imaging data using HCT116 tumour-bearing mice showed a 2.5 %ID g-1 tumour uptake of [18F]trifluridine at 60 minutes post-injection, with bone uptake becoming a prominent feature thereafter. In vivo metabolite analysis of selected tissues revealed the presence of the original radiolabelled nucleoside analogue, together with deglycosylated and phosphorylated [18F]trifluridine as the main metabolites. Our findings suggest a potential role for [18F]trifluridine as a PET radiotracer for elucidation of drug mechanism of action.

Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents

A series of new aryloxyacetamide derivatives 10a-s and 14a-m are designed and synthesized. Their protective activities against the glutamate-induced cell death were investigated in differentiated rat pheochromocytoma cells (PC12 cells). Most compounds exhibited neuroprotective effects, especially for 10m, 10r, 14b and 14c, which showed potential protection of PC12 cells at three doses (0.1, 1.0, 10 μM). MTT assay, Hoechst 33342/PI double staining, and high content screening (HCS) revealed that pretreatment of the cells with 10m, 10r, 14b and 14c has significantly decreased the extent of cell apoptosis in a dose-dependent manner. The results of western blot analysis demonstrated these compounds suppressed apoptosis of glutamate-induced PC12 cells via caspase-3 pathway. These compounds can be lead compounds for further discovery of neuroprotective agents for treating cerebral ischemic stroke. Basic structure-activity relationships are also presented.