C₃₈H₄₆N₂O₅

Base Information

• Chemical Name: C₃₈H₄₆N₂O₅
• CAS No.: 1280736-84-6
• Molecular Formula: C₃₈H₄₆N₂O₅
• Molecular Weight: 610.794
• Mol file: 1280736-84-6.mol

Synonyms:C₃₈H₄₆N₂O₅

Chemical Property of C₃₈H₄₆N₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₄₆N₂O₅

There total 5 articles about C₃₈H₄₆N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

t-butyl (1S,2S,3S)-3-benzyl-2-aminocyclopentane-1-carboxylate (820236-58-6) + (S,S,S)-2-[N-(benzyloxycarbonyl)amino]-3-benzylcyclopentanecarboxylic acid (1280736-81-3) → C38H46N2O5 (1280736-84-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.12.007

Reference yield:

tert-butyl (1S,2S,3S,αS)-3-benzyl-2-(N-benzyl-N-α-methylbenzylamino)-cyclopentane-1-carboxylate (820236-49-5) → C38H46N2O5 (1280736-84-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 20 % Pd(OH)2/C; hydrogen / ethyl acetate / 16 h / 20 °C / 3800.26 Torr

2: triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / chloroform / 16 h / 20 °C / Inert atmosphere

With 20 % Pd(OH)2/C; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; ethyl acetate;

DOI:10.1016/j.tetasy.2010.12.007

Reference yield:

tert-butyl (1R,2S,3S,αS)-3-benzyl-2-(N-benzyl-N-α-methylbenzylamino)-cyclopentane-1-carboxylate (816444-33-4) → C38H46N2O5 (1280736-84-6)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium tert-butylate; tert-butyl alcohol / 8 h / Reflux; Inert atmosphere

2: 20 % Pd(OH)2/C; hydrogen / ethyl acetate / 16 h / 20 °C / 3800.26 Torr

3: triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / chloroform / 16 h / 20 °C / Inert atmosphere

With 20 % Pd(OH)2/C; potassium tert-butylate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; tert-butyl alcohol; In tetrahydrofuran; dichloromethane; chloroform; ethyl acetate;

DOI:10.1016/j.tetasy.2010.12.007

upstream raw materials:

t-butyl (1S,2S,3S)-3-benzyl-2-aminocyclopentane-1-carboxylate

(S,S,S)-2-[N-(benzyloxycarbonyl)amino]-3-benzylcyclopentanecarboxylic acid

tert-butyl (1S,2S,3S,αS)-3-benzyl-2-(N-benzyl-N-α-methylbenzylamino)-cyclopentane-1-carboxylate

tert-butyl (1R,2S,3S,αS)-3-benzyl-2-(N-benzyl-N-α-methylbenzylamino)-cyclopentane-1-carboxylate

Downstream raw materials:

C₃₀H₄₀N₂O₃

C₃₄H₃₈N₂O₅

C₅₁H₆₁N₃O₆

C₆₄H₇₆N₄O₇