(2R,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)octadecane-1,3-diol

Base Information

Chemical Name:(2R,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)octadecane-1,3-diol
CAS No.:1606994-01-7
Molecular Formula:C₃₇H₆₁NO₄
Molecular Weight:583.896
Hs Code.:

Synonyms:(2R,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)octadecane-1,3-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)octadecane-1,3-diol

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Technology Process of (2R,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)octadecane-1,3-diol

There total 7 articles about (2R,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)octadecane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1606994-02-8
ethyl (2S,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)-3-hydroxyoctadecanoate

: 1606994-01-7
(2R,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)octadecane-1,3-diol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/ejoc.201301766 DOI:10.1002/ejoc.201301766

Reference yield:

: 629-80-1
n-hexadecylaldehyde

: 1606994-01-7
(2R,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)octadecane-1,3-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: (R)-t-Bu₂VANOL; triphenylborane / toluene / 0.5 h / 80 °C / Inert atmosphere; Schlenk technique

1.2: 24 h / -10 °C / Molecular sieve; Inert atmosphere; Schlenk technique

2.1: dichloromethane / 12 h / Inert atmosphere; Reflux

3.1: sodium hydroxide / ethanol; water / 0.33 h / 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; triphenylborane; (R)-t-Bu₂VANOL; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1002/ejoc.201301766

Reference yield:

: 1606993-91-2
ethyl (2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-pentadecylaziridine-2-carboxylate

: 1606994-01-7
(2R,3R)-2-((bis(4-methoxy-3,5-dimethylphenyl)methyl)amino)octadecane-1,3-diol

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 12 h / Inert atmosphere; Reflux

2: sodium hydroxide / ethanol; water / 0.33 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/ejoc.201301766