Technology Process of ethyl 8-amino-2-[3-(trifluoromethoxy)phenyl]-1,7-naphthyridine-5-carboxylate
There total 6 articles about ethyl 8-amino-2-[3-(trifluoromethoxy)phenyl]-1,7-naphthyridine-5-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 8-amino-2-hydroxy-1,7-naphthyridine-5-carboxylate;
With
triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
1,4-dioxane;
at 20 ℃;
for 1h;
Inert atmosphere;
(3-(trifluoromethoxy)phenyl)boronic acid;
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
1,4-dioxane; water;
at 90 ℃;
for 3h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere
2.1: ammonium hydroxide / ethanol / 20 °C / Inert atmosphere
3.1: hydrogen bromide / acetic acid / 3 h / 60 - 70 °C / Inert atmosphere
4.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
4.2: 3 h / 90 °C / Inert atmosphere
With
ammonium hydroxide; tetrakis(triphenylphosphine) palladium(0); hydrogen bromide; potassium carbonate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
1,4-dioxane; ethanol; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / acetonitrile / 15 h / 80 °C / Inert atmosphere
2.1: potassium acetate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere
4.1: ammonium hydroxide / ethanol / 20 °C / Inert atmosphere
5.1: hydrogen bromide / acetic acid / 3 h / 60 - 70 °C / Inert atmosphere
6.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
6.2: 3 h / 90 °C / Inert atmosphere
With
ammonium hydroxide; tetrakis(triphenylphosphine) palladium(0); hydrogen bromide; potassium acetate; potassium carbonate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
1,4-dioxane; ethanol; water; acetic acid; acetonitrile;
