4-((4-((4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)phenyl)amino)pyrimidin-2-yl)amino)-2,3,5,6-tetradeuterobenzonitrile

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Chemical Name:4-((4-((4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)phenyl)amino)pyrimidin-2-yl)amino)-2,3,5,6-tetradeuterobenzonitrile
CAS No.:1331866-36-4
Molecular Formula:C₁₉H₁₆BrN₅
Molecular Weight:406.178
Hs Code.:

Synonyms:4-((4-((4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)phenyl)amino)pyrimidin-2-yl)amino)-2,3,5,6-tetradeuterobenzonitrile

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Chemical Property of 4-((4-((4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)phenyl)amino)pyrimidin-2-yl)amino)-2,3,5,6-tetradeuterobenzonitrile

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Technology Process of 4-((4-((4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)phenyl)amino)pyrimidin-2-yl)amino)-2,3,5,6-tetradeuterobenzonitrile

There total 5 articles about 4-((4-((4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)phenyl)amino)pyrimidin-2-yl)amino)-2,3,5,6-tetradeuterobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1331866-33-1
4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)aniline

: 1331866-35-3
2,3,5,6-tetradeutero-4-((4-chloropyrimidin-2-yl)amino)benzonitrile

: 1331866-36-4
4-((4-((4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)phenyl)amino)pyrimidin-2-yl)amino)-2,3,5,6-tetradeuterobenzonitrile

Guidance literature:: at 150 ℃; for 1h;

Reference yield:

: 61357-76-4
4-bromobenzen-2,3,5,6-d₄-amine

: 1331866-36-4
4-((4-((4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)phenyl)amino)pyrimidin-2-yl)amino)-2,3,5,6-tetradeuterobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: water / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 120 °C

2: 7 h / 185 °C

3: trichlorophosphate / 0.5 h / Reflux

4: 1 h / 150 °C

With water; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield:

: 4165-61-1
aniline-d5

: 1331866-36-4
4-((4-((4-bromo-3,5-dideutero-2,6-bis(trideuteromethyl)phenyl)amino)pyrimidin-2-yl)amino)-2,3,5,6-tetradeuterobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4,4-dibromo-5-methyl-2,4-dihydro-3H-pyrazol-3-one / acetic acid / 15.5 h / 20 °C

1.2: pH > 7

2.1: water / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 120 °C

3.1: 7 h / 185 °C

4.1: trichlorophosphate / 0.5 h / Reflux

5.1: 1 h / 150 °C

With 4,4-dibromo-5-methyl-2,4-dihydro-3H-pyrazol-3-one; water; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In acetic acid; N,N-dimethyl-formamide;