1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

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Chemical Name:1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide
CAS No.:1449320-11-9
Molecular Formula:C₂₆H₂₂F₂N₆OS
Molecular Weight:504.563
Hs Code.:

Synonyms:1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

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Chemical Property of 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

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Technology Process of 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

There total 8 articles about 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.8%

: 1449320-11-9
1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

Guidance literature:: With methanol; potassium carbonate; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield: 53.4%

: C₃₃H₂₈F₂N₆O₃S₂

: 1449320-11-9
1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

Guidance literature:: With methanol; potassium carbonate; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1449318-35-7
1-benzyl-1H-pyrazol-4-carboxylic acid (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

: 1449320-11-9
1-benzyl-1H-pyrazol-4-carboxylic acid {5-[5-(3,3-difluoroazetidin-1-ylmethyl)thiophen-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 4 h / 20 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.33 h / 150 °C / Microwave irradiation

3.1: tetrahydrofuran / 3 h / 20 °C / Molecular sieve

3.2: 18 h / 20 °C

4.1: methanol; potassium carbonate / 0.5 h / 100 °C / Microwave irradiation

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 2.1: |Suzuki Coupling;