(Rp,Sp)-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino)-(2,2,2-trifluoroethyl)phosphoramidites

Base Information

Chemical Name:(Rp,Sp)-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino)-(2,2,2-trifluoroethyl)phosphoramidites
CAS No.:125264-21-3
Molecular Formula:C₃₉H₄₇F₃N₃O₈P
Molecular Weight:773.786
Hs Code.:

Synonyms:(Rp,Sp)-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino)-(2,2,2-trifluoroethyl)phosphoramidites

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Chemical Property of (Rp,Sp)-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino)-(2,2,2-trifluoroethyl)phosphoramidites

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Technology Process of (Rp,Sp)-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino)-(2,2,2-trifluoroethyl)phosphoramidites

There total 1 articles about (Rp,Sp)-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino)-(2,2,2-trifluoroethyl)phosphoramidites which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 161000-51-7
chloro-N,N-diisopropylamino-(2,2,2-trifluoroethoxy)phosphine

: 125264-21-3
(Rp,Sp)-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino)-(2,2,2-trifluoroethyl)phosphoramidites

Guidance literature:: With diisopropylamine; In dichloromethane; for 0.333333h; Ambient temperature;
DOI:10.1139/v94-193

Reference yield:

: 125264-21-3
(Rp,Sp)-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino)-(2,2,2-trifluoroethyl)phosphoramidites

: (Sp)-5'-O-(4,4'-dimethoxytrityl)thymidylyl-3',5'-thymidine (2,2,2-trifluoroethyl)phosphate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrazole / acetonitrile / 4 h / Ambient temperature

2: iodine, 2,6-lutidine / tetrahydrofuran; H₂O / 0.17 h

3: tetrabutylammonium fluoride / tetrahydrofuran; H₂O / 0.33 h / Ambient temperature

With 2,6-dimethylpyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; iodine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1139/v94-193

Reference yield:

: 125264-21-3
(Rp,Sp)-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino)-(2,2,2-trifluoroethyl)phosphoramidites

: 161000-55-1
(Rp)-5'-O-(4,4'-dimethoxytrityl)thymidylyl-3',5'-3'-O-<(1,1-dimethylethyl)dimethylsilyl>thymidine (2,2,2-trifluoroethyl)phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole / acetonitrile / 4 h / Ambient temperature

2: iodine, 2,6-lutidine / tetrahydrofuran; H₂O / 0.17 h

With 2,6-dimethylpyridine; 1H-tetrazole; iodine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1139/v94-193