3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid
CAS No.:1455089-62-9
Molecular Formula:C₂₃H₂₅N₃O₅
Molecular Weight:423.469
Hs Code.:

Synonyms:3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

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Chemical Property of 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

There total 5 articles about 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455094-05-9
methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate

: 1455089-62-9
3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 5h;

Reference yield:

: 7-bromo-4-hydroxyisoquinoline-3-carboxylic acid methyl ester

: 1455089-62-9
3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 16 h / 60 °C

2: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere

3: palladium on activated carbon; hydrogen / ethanol; ethyl acetate / 16 h / 20 °C

4: methanol / 4 h / 150 °C / Microwave irradiation

5: sodium hydroxide / methanol; water / 5 h / 20 °C

With copper(l) iodide; palladium on activated carbon; hydrogen; potassium carbonate; L-proline; potassium iodide; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1455093-98-7
methyl 4-(benzyloxy)-7-bromoisoquinoline-3-carboxylate

: 1455089-62-9
3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere

2: palladium on activated carbon; hydrogen / ethanol; ethyl acetate / 16 h / 20 °C

3: methanol / 4 h / 150 °C / Microwave irradiation

4: sodium hydroxide / methanol; water / 5 h / 20 °C

With copper(l) iodide; palladium on activated carbon; hydrogen; potassium carbonate; L-proline; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate;