methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate
CAS No.:1455094-05-9
Molecular Formula:C₂₄H₂₇N₃O₅
Molecular Weight:437.495
Hs Code.:

Synonyms:methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate

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Chemical Property of methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate

Chemical Property:

Purity/Quality:

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Technology Process of methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate

There total 4 articles about methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25307-82-8
methyl 3-amino-2,2-dimethylpropionate

: 1455094-02-6
methyl 4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxylate

: 1455094-05-9
methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate

Guidance literature:: In methanol; at 150 ℃; for 4h; Microwave irradiation;

Reference yield:

: 7-bromo-4-hydroxyisoquinoline-3-carboxylic acid methyl ester

: 1455094-05-9
methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 16 h / 60 °C

2: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere

3: palladium on activated carbon; hydrogen / ethanol; ethyl acetate / 16 h / 20 °C

4: methanol / 4 h / 150 °C / Microwave irradiation

With copper(l) iodide; palladium on activated carbon; hydrogen; potassium carbonate; L-proline; potassium iodide; In methanol; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1455093-98-7
methyl 4-(benzyloxy)-7-bromoisoquinoline-3-carboxylate

: 1455094-05-9
methyl 3-(4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxamido)-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere

2: palladium on activated carbon; hydrogen / ethanol; ethyl acetate / 16 h / 20 °C

3: methanol / 4 h / 150 °C / Microwave irradiation

With copper(l) iodide; palladium on activated carbon; hydrogen; potassium carbonate; L-proline; In methanol; ethanol; dimethyl sulfoxide; ethyl acetate;