2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide

Base Information

Chemical Name:2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide
CAS No.:1610436-28-6
Molecular Formula:C₂₁H₂₀ClN₂O₂P
Molecular Weight:398.829
Hs Code.:

Synonyms:2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide

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Chemical Property of 2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide

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Technology Process of 2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide

There total 1 articles about 2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1610436-26-4
{[6-(aminomethyl)pyridin-2-yl]methyl}diphenylphosphine oxide

: 79-04-9
chloroacetyl chloride

: 1610436-28-6
2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide

Guidance literature:: {[6-(aminomethyl)pyridin-2-yl]methyl}diphenylphosphine oxide; chloroacetyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 15h;

Inert atmosphere;
DOI:10.1039/c3dt53611d

Reference yield: 97.0%

: 719-80-2
Ethyl diphenylphosphinite

: 1610436-28-6
2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide

: 1610436-30-0
2-(diphenylphosphoryl)-N-{[6-((diphenylphosphoryl)methyl)-pyridin-2-yl]methyl}acetamide

Guidance literature:: Ethyl diphenylphosphinite; 2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide; In o-xylene; at 120 ℃; for 16h; Inert atmosphere;

Inert atmosphere;
DOI:10.1039/c3dt53611d

Reference yield:

: 1610436-28-6
2-chloro-N-{[6-((diphenylphosphoryl)methyl)pyridin-2-yl]-methyl}acetamide

: [Yb(2-{[2-(diphenylphosphoryl)acetamido]methyl}-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide)(NO₃)3]

Guidance literature:: Multi-step reaction with 3 steps

1.1: o-xylene / 16 h / 120 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: dichloromethane / 18 h / 23 °C

2.2: Inert atmosphere

3.1: methanol / 2 h / 23 °C / Inert atmosphere

In methanol; dichloromethane; o-xylene;
DOI:10.1039/c3dt53611d