3-((3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Base Information

Chemical Name:3-((3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid
CAS No.:1445879-05-9
Molecular Formula:C₃₀H₃₃N₅O₇S
Molecular Weight:607.687
Hs Code.:

Synonyms:3-((3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Chemical Property of 3-((3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Technology Process of 3-((3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

There total 8 articles about 3-((3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1445880-25-0
methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

: 1445879-05-9
3-((3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; at 20 ℃; for 16h;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445879-05-9
3-((3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / 18 h / 100 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / 2 h / 90 °C

2.2: 0.5 h / 0 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 4 h / 80 °C / Inert atmosphere

4.1: ethanol / 16 h / 90 °C

5.1: lithium hydroxide; water / methanol / 16 h / 20 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; water; sodium hydrogencarbonate; N,N-dimethyl-formamide; lithium hydroxide; In 1,4-dioxane; methanol; ethanol; water;

Reference yield:

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445879-05-9
3-((3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 4 h / 80 °C / Inert atmosphere

2: ethanol / 16 h / 90 °C

3: lithium hydroxide; water / methanol / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium hydrogencarbonate; lithium hydroxide; In 1,4-dioxane; methanol; ethanol; water;