methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

Base Information

Chemical Name:methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate
CAS No.:1445880-25-0
Molecular Formula:C₃₁H₃₅N₅O₇S
Molecular Weight:621.714
Hs Code.:

Synonyms:methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

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Chemical Property of methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

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Technology Process of methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

There total 7 articles about methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: methyl 3-amino-5-isopropoxybenzoate

: 1445880-24-9
4-chloro-N-cyclopentyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

: 1445880-25-0
methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

Guidance literature:: In ethanol; at 90 ℃; for 16h;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445880-25-0
methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / 18 h / 100 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / 2 h / 90 °C

2.2: 0.5 h / 0 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 4 h / 80 °C / Inert atmosphere

4.1: ethanol / 16 h / 90 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; water;

Reference yield:

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445880-25-0
methyl3-(3-(N-cyclopentylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-isopropoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 4 h / 80 °C / Inert atmosphere

2: ethanol / 16 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; ethanol; water;