(-)-2-methylenesuccinic acid bis(2-isopropyl-5-methylcyclohexyl)ester

Base Information

• Chemical Name: (-)-2-methylenesuccinic acid bis(2-isopropyl-5-methylcyclohexyl)ester
• CAS No.: 125517-97-7
• Molecular Formula: C₂₅H₄₂O₄
• Molecular Weight: 406.606
• Mol file: 125517-97-7.mol

Synonyms:(-)-2-methylenesuccinic acid bis(2-isopropyl-5-methylcyclohexyl)ester

Chemical Property of (-)-2-methylenesuccinic acid bis(2-isopropyl-5-methylcyclohexyl)ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (-)-2-methylenesuccinic acid bis(2-isopropyl-5-methylcyclohexyl)ester

There total 1 articles about (-)-2-methylenesuccinic acid bis(2-isopropyl-5-methylcyclohexyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(-)-menthol (2216-51-5) + itaconic acid anhydride (2170-03-8) → (-)-2-methylenesuccinic acid bis(2-isopropyl-5-methylcyclohexyl)ester (125517-97-7)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 36h; Heating;

DOI:10.1055/s-2006-958977

Reference yield: 11.0%

(-)-2-methylenesuccinic acid bis(2-isopropyl-5-methylcyclohexyl)ester (125517-97-7) + 2-amino-benzenethiol (137-07-5) → 2-(2-aminophenylsulfanylmethyl)succinic acid bis(2-isopropyl-5-methylcyclohexyl)ester (934564-07-5) + 2-(2-aminophenylsulfanylmethyl)succinic acid bis(2-isopropyl-5-methylcyclohexyl)ester

Guidance literature:

With acetic acid; at 20 ℃; for 36h;

DOI:10.1055/s-2006-958977

Reference yield:

(-)-2-methylenesuccinic acid bis(2-isopropyl-5-methylcyclohexyl)ester (125517-97-7) → (3R)-2-(4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl)-N-(1R-phenylethyl)acetamide

Guidance literature:

Multi-step reaction with 4 steps

1: 11 percent / glacial acetic acid / 36 h / 20 °C

2: 86 percent / AcOH; HCl / 12 h / Heating

3: 88 percent / N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; DMAP / tetrahydrofuran / 4 h / 20 °C

4: 90 percent / N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; DMAP / tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; dmap; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1: Michael addition reaction;

DOI:10.1055/s-2006-958977

upstream raw materials:

(-)-menthol

itaconic acid anhydride

Downstream raw materials:

2-(2-aminophenylsulfanylmethyl)succinic acid bis(2-isopropyl-5-methylcyclohexyl)ester

2-(2-aminophenylsulfanylmethyl)succinic acid