(3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone

Base Information

Chemical Name:(3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone
CAS No.:400863-51-6
Molecular Formula:C₁₉H₁₆F₃N₃O₂S
Molecular Weight:407.416
Hs Code.:

Synonyms:(3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone

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Technology Process of (3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone

There total 5 articles about (3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 104960-56-7
3-amino-2-carboxy-4-trifluoromethyl-6-phenylthieno<2,3-b>pyridine

: 400863-51-6
(3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2014.01.075

Reference yield:

: 299165-10-9
ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester

: 400863-51-6
(3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2014.01.075

Reference yield:

: 104960-49-8
2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 400863-51-6
(3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / N,N-dimethyl-formamide; water / 20 °C

2: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.01.075