104960-56-7

Usage

Uses

Used in Medicinal Chemistry:
3-AMINO-6-PHENYL-4-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID is used as a building block for the synthesis of new pharmaceutical compounds due to its diverse functional groups that can be modified to create analogs with potential therapeutic effects.
Used in Drug Development:
In the pharmaceutical industry, 3-AMINO-6-PHENYL-4-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID is utilized as a precursor in the development of novel drugs, leveraging its structural features to design molecules with specific biological activities and potential medicinal applications.
Used in Research and Discovery:
3-AMINO-6-PHENYL-4-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID serves as a subject of research for scientists exploring its pharmacological properties and potential interactions with biological targets, which may lead to the discovery of new therapeutic agents or a better understanding of disease mechanisms.
The carboxylic acid group present in the compound suggests that it can be used to form esters, amides, or other derivatives, expanding its potential applications in various chemical and pharmaceutical processes. Further research on 3-AMINO-6-PHENYL-4-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID and its derivatives may reveal additional uses and applications in different industries.

Upstream product

• 98-86-2 acetophenone 
• 299165-10-9 ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester 
• 82959-36-2 1-benzoyl-2-(1-morpholino)-3,3,3-trifluoro-1-propene 
• 104960-49-8 2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 104960-54-5 4-trifluoromethyl-6-phenyl-3-cyano-2-pyridylthioacetic acid 

Downstream Products

• 104960-61-4 6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone 
• 104960-57-8 3-amino-4-trifluoromethyl-6-phenylthieno<2,3-b>pyridine 
• 400863-51-6 (3-amino-6-phenyl-4-trifluoromethylthieno[2,3-b]pyridin-2-yl)morpholin-4-ylmethanone 
• 1581726-24-0 C₂₄H₂₅F₃N₄O₃S 
• 1581726-26-2 C₂₀H₁₆F₃N₃O₂S 
• 1581726-25-1 C₁₉H₁₇F₃N₄OS 
• 352024-84-1 C₂₀H₁₈F₃N₃OS 
• 827008-47-9 (3-amino-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-methylpiperazin-1-yl)methanone 
• 1581726-27-3 C₁₉H₁₆F₃N₃OS₂ 
• 1581726-28-4 C₂₀H₁₈F₃N₃OS 
• 1581726-29-5 3-amino-N-benzyl-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide 
• 1581726-30-8 C₂₀H₁₄F₃N₃OS₂ 
• 1581726-31-9 C₂₂H₁₆F₃N₃OS₂ 
• 104960-59-0 N-(4-trifluoromethyl-6-phenylthieno<2,3-b>-3-pyridyl)-N'-(4-chlorophenyl)urea 

Relevant academic research and scientific papers

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.

CYCLIZATION OF NITRILES. XVIII. SYNTHESIS AND SOME TRANSFORMATIONS OF 6-ARYL-4-TRIFLUOROMETHYL-3-CYANO-2(1H)-PYRIDINETHIONES

The reaction of 3-benzoyl- and 3-(2-thenoyl)-1,1,1-trifluoroacetone and also of 1-benzoyl- and 1-(2-thenoyl)-2-(1-morpholino)-3,3,3-trifluoro-1-propenes with cyanothioacetamide provides a convenient method for the production of 6-phenyl- and 6-(2-thienyl)-4-trifluoromethyl-3-cyano-2(1H)-pyridine thiones, which are used in the synthesis of substituted 3-aminothienopyridines and other condensed heterocyclic systems.