tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate

Base Information

• Chemical Name: tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate
• CAS No.: 1533519-91-3
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.37
• Mol file: 1533519-91-3.mol

Synonyms:tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate

Chemical Property of tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl(4-cyclopropylnaphthalen-1-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate

There total 1 articles about tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 1-amino-4-cyclopropylnaphthalene hydrochloride (1533519-92-4) → tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate (1533519-91-3)

Guidance literature:

With triethylamine; In ethanol;

Reference yield:

tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate (1533519-91-3) → 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-yl)thio)acetic acid methyl ester (1533519-85-5)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / ethanol

2: potassium hydroxide / dichloromethane

3: N,N-dimethyl-formamide / 50 - 55 °C

4: potassium hydrogencarbonate / N,N-dimethyl-formamide; water / 90 - 140 °C

5: sodium carbonate / N,N-dimethyl-formamide / 27 - 35 °C / Large scale

With hydrogenchloride; sodium carbonate; potassium hydrogencarbonate; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 4-cyclopropylnaphthalen-1-ylcarbamate (1533519-91-3) → 4-(4-cyclopropylnaphthalen-1-yl)-4Η-1,2,4-triazole-3-thiol (1533519-84-4)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol

2: potassium hydroxide / dichloromethane

3: N,N-dimethyl-formamide / 50 - 55 °C

4: potassium hydrogencarbonate / N,N-dimethyl-formamide; water / 90 - 140 °C

With hydrogenchloride; potassium hydrogencarbonate; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

di-tert-butyl dicarbonate

1-amino-4-cyclopropylnaphthalene hydrochloride

Downstream raw materials:

2-((5-amino-4-(4-cyclopropyl-naphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid methyl ester

2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid

1-amino-4-cyclopropylnaphthalene hydrochloride

N-(4-cyclopropylnaphthalen-1-yl)-2-formylhydrazine-1-thiocarboxamide

Refernces