N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide

Base Information

• Chemical Name: N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide
• CAS No.: 1533519-86-6
• Molecular Formula: C15H15N3OS
• Molecular Weight: 285.37
• Mol file: 1533519-86-6.mol

Synonyms:N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide;4-(3- mercapto -4H-1,2,4-triazol-4-yl)- 1-cycpropylnaphthalene;Lesinurad Impurity 33

Chemical Property of N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide

Chemical Property:

• Boiling Point: 456.9±38.0 °C(Predicted)
• PKA: 8?+-.0.70(Predicted)
• PSA: 85.25000
• Density: 1.375±0.06 g/cm3(Predicted)
• LogP: 4.15530

Purity/Quality:

98%Min ^*data from raw suppliers

N-(4-Cyclopropylnaphthalen-1-yl)-2-formylhydrazinecarbothioamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide

There total 10 articles about N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-cyclopropylnaphthalene-4-yl isothiocyanate (878671-95-5) + formic acid hydrazide (624-84-0) → N-(4-cyclopropylnaphthalen-1-yl)-2-formylhydrazine-1-thiocarboxamide (1533519-86-6)

Guidance literature:

In ethyl acetate; at 60 ℃; for 2h; Temperature;

Reference yield:

1-cyclopropyl-naphthalene (25033-19-6) → N-(4-cyclopropylnaphthalen-1-yl)-2-formylhydrazine-1-thiocarboxamide (1533519-86-6)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid / 0 - 20 °C

2: hydrazine hydrate / methanol / Reflux

3: potassium hydroxide / dichloromethane

4: N,N-dimethyl-formamide / 50 - 55 °C

With nitric acid; hydrazine hydrate; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1-cyclopropylnaphthalene-4-yl isothiocyanate (878671-95-5) + formic acid hydrazide (624-84-0) → N-(4-cyclopropylnaphthalen-1-yl)-2-formylhydrazine-1-thiocarboxamide (1533519-86-6) + C28H26N4S2

Guidance literature:

In N,N-dimethyl-formamide; at 20 - 30 ℃; for 5h; Temperature;

upstream raw materials:

1-amino-4-cyclopropylnaphthalene

1-Bromonaphthalene

1-cyclopropyl-naphthalene

1-cyclopropyl-4-nitronaphthalene

Downstream raw materials:

2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid

4-(4-cyclopropylnaphthalen-1-yl)-4Η-1,2,4-triazole-3-thiol

2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-yl)thio)acetic acid methyl ester

(-)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid

Refernces

• 1、 -. "Optically pure thioacetic compound". . . Retrieved 2016/12/26.
• 2、 -. "THIO-1,2,4-TRIAZOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME". . . Retrieved 2015/01/09.