(4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride

Base Information

Chemical Name:(4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride
CAS No.:1053265-32-9
Molecular Formula:C₂₆H₂₅ClN₂O₂*ClH
Molecular Weight:469.411
Hs Code.:

Synonyms:(4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride

Suppliers and Price of (4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride

There total 20 articles about (4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: methyl (4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylate

: 1053265-32-9
(4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride

Guidance literature:: methyl (4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylate; With lithium hydroxide monohydrate; In tetrahydrofuran; ethanol; water; at 50 ℃; for 15h; Large scale;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 35 ℃; Solvent; Reagent/catalyst; Large scale;
DOI:10.1021/acs.oprd.9b00364

Reference yield: 88.0%

: 124-38-9,18923-20-1
carbon dioxide

: (4aR)-8-bromo-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline

: 1053265-32-9
(4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride

Guidance literature:: (4aR)-8-bromo-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline; With isopropylmagnesium chloride; In tetrahydrofuran; 2-methyltetrahydrofuran; at -5 - 0 ℃; for 0.916667h;

With n-butyllithium; In tetrahydrofuran; 2-methyltetrahydrofuran; hexane; at -5 - 0 ℃; for 1.16667h;

carbon dioxide; Solvent; Further stages;
DOI:10.1021/acs.oprd.9b00364

Reference yield:

: 78348-26-2
1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester hydrochloride

: 1053265-32-9
(4aR)-3-[[2-(4-chlorophenyl)phenyl]methyl]-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / water; ethyl acetate / 1 h / Large scale

2.1: Chiralpak IA 20 μm / methanol / Resolution of racemate; Large scale

3.1: pyridine / tetrahydrofuran / 3 h / 20 - 25 °C / Large scale

4.1: palladium on activated charcoal; hydrogen; acetic acid / methanol / 5 h / 50 °C / 750.08 Torr / Large scale

5.1: diisobutylaluminium hydride / tetrahydrofuran / 4 h / 50 °C

6.1: triethylamine; potassium iodide / toluene / Reflux

7.1: N-Bromosuccinimide / dichloromethane; acetonitrile / 1 h / 0 °C

8.1: isopropylmagnesium chloride / tetrahydrofuran; 2-methyltetrahydrofuran / 0.92 h / -5 - 0 °C

8.2: 1.17 h / -5 - 0 °C

With pyridine; N-Bromosuccinimide; palladium on activated charcoal; hydrogen; isopropylmagnesium chloride; diisobutylaluminium hydride; acetic acid; triethylamine; potassium iodide; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/acs.oprd.9b00364