1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone

Base Information

• Chemical Name: 1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone
• CAS No.: 1150635-18-9
• Molecular Formula: C₁₆H₁₂ClN₃O
• Molecular Weight: 297.744
• Mol file: 1150635-18-9.mol

Synonyms:1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone

Chemical Property of 1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone

There total 7 articles about 1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

phenylacetylene (536-74-3) + 4-chlorobenzoylmethyl bromide (536-38-9) → 1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone (1150635-18-9)

Guidance literature:

With sodium azide; methyl 2-{[1-methyl-2-(2-hydroxy-5-nitrophenyl)methylidenenitrilo]ethyl}amino-1-cyclopentenedithiocarboxylate; In tetrahydrofuran; water; for 0.533333h; Reagent/catalyst; Reflux;

DOI:10.17344/acsi.2018.4159

Reference yield: 91.0%

2-azido-4'-chloroacetophenone (26086-60-2) + phenylacetylene (536-74-3) → 1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone (1150635-18-9)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In water; at 20 ℃; for 4h;

DOI:10.1080/10242422.2017.1352585

Reference yield: 79.0%

1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone (25917-49-1) + phenylacetylene (536-74-3) → 1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone (1150635-18-9)

Guidance literature:

With copper(l) iodide; sodium azide; In decaethylene glycol; water; at 20 ℃; for 0.5h; regioselective reaction;

DOI:10.1016/j.tetlet.2009.02.107

upstream raw materials:

1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone

phenylacetylene

4-chlorobenzoylmethyl bromide

1-(p-chlorophenyl)ethyl alcohol

Downstream raw materials:

C₁₆H₁₄ClN₃O

1-(2-(2-chloro-4-fluorobenzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole

1-(2-(4-chlorobenzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole

1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole