1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole

Base Information

• Chemical Name: 1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole
• CAS No.: 1415406-48-2
• Molecular Formula: C₂₃H₂₀ClN₃O
• Molecular Weight: 389.884
• Mol file: 1415406-48-2.mol

Synonyms:1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole

Chemical Property of 1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole

There total 4 articles about 1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C16H14ClN3O (1415406-26-6) + benzyl bromide (100-39-0) → 1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole (1415406-48-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 2h;

DOI:10.1016/j.tetlet.2012.09.129

Reference yield:

4-chlorobenzoylmethyl bromide (536-38-9) → 1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole (1415406-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide; copper(l) iodide / water / 2 h / 25 - 30 °C

2: sodium tetrahydroborate / methanol / 16 h / 25 - 30 °C

3: sodium hydride / N,N-dimethyl-formamide / 2 h

With sodium tetrahydroborate; copper(l) iodide; sodium azide; sodium hydride; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2012.09.129

Reference yield:

1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone (1150635-18-9) → 1-(2-(benzyloxy)-2-(4-chlorophenyl)ethyl)-4-phenyl-1H-1,2,3-triazole (1415406-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 16 h / 25 - 30 °C

2: sodium hydride / N,N-dimethyl-formamide / 2 h

With sodium tetrahydroborate; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2012.09.129

upstream raw materials:

4-chlorobenzoylmethyl bromide

1-(4-chlorophenyl)-2-(4-phenyl-1H-1,2,3-triazole-1-yl)-1-ethanone

C₁₆H₁₄ClN₃O

benzyl bromide