N⁴-(4-Azidobenzyloxycarbonyl)-N¹,N⁸-bis(nitroguanidino)spermidine

Base Information

• Chemical Name: N⁴-(4-Azidobenzyloxycarbonyl)-N¹,N⁸-bis(nitroguanidino)spermidine
• CAS No.: 158474-92-1
• Molecular Formula: C₁₇H₂₆N₁₂O₆
• Molecular Weight: 494.47
• Mol file: 158474-92-1.mol

Synonyms:N⁴-(4-Azidobenzyloxycarbonyl)-N¹,N⁸-bis(nitroguanidino)spermidine

Chemical Property of N⁴-(4-Azidobenzyloxycarbonyl)-N¹,N⁸-bis(nitroguanidino)spermidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-(4-Azidobenzyloxycarbonyl)-N¹,N⁸-bis(nitroguanidino)spermidine

There total 5 articles about N⁴-(4-Azidobenzyloxycarbonyl)-N¹,N⁸-bis(nitroguanidino)spermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine (2946-89-6) + (4-Amino-butyl)-(3-amino-propyl)-carbamic acid 4-azido-benzyl ester (158474-91-0) → N4-(4-Azidobenzyloxycarbonyl)-N1,N8-bis(nitroguanidino)spermidine (158474-92-1)

Guidance literature:

In methanol; for 72h; Ambient temperature;

DOI:10.1039/c39940002613

Reference yield:

N-(3-aminopropyl)-1,4-diaminobutane (124-20-9) → N4-(4-Azidobenzyloxycarbonyl)-N1,N8-bis(nitroguanidino)spermidine (158474-92-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / H₂O / acetonitrile / 7 h

2: 92 percent / iPrEtN / tetrahydrofuran / 24 h / 25 °C

3: 82 percent / NH₄OH, H₂O / methanol / 144 h / 25 °C

4: 81 percent / methanol / 72 h / 25 °C

With ammonium hydroxide; water; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1039/a806355i

Reference yield:

[4-(2,2,2-Trifluoro-acetylamino)-butyl]-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 4-azido-benzyl ester (158474-90-9) → N4-(4-Azidobenzyloxycarbonyl)-N1,N8-bis(nitroguanidino)spermidine (158474-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / NH₄OH, H₂O / methanol / 144 h / 25 °C

2: 81 percent / methanol / 72 h / 25 °C

With ammonium hydroxide; water; In methanol;

DOI:10.1039/a806355i

upstream raw materials:

3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine

(4-Amino-butyl)-(3-amino-propyl)-carbamic acid 4-azido-benzyl ester

N-(3-aminopropyl)-1,4-diaminobutane

[4-(2,2,2-Trifluoro-acetylamino)-butyl]-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 4-azido-benzyl ester

Downstream raw materials:

N-(4-guanidinylbutyl)-N-(3-guanidinylpropyl)amine