2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol

Base Information

Chemical Name:2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol
CAS No.:879275-42-0
Molecular Formula:C₂₁H₂₃FN₄O
Molecular Weight:366.438
Hs Code.:

Synonyms:2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol

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Chemical Property of 2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol

Chemical Property:

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Technology Process of 2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol

There total 1 articles about 2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 879275-33-9
(R)-1-piperidin-3-ylmethyl-carbamic acid tert-butyl ester

: 879274-80-3
2-(4-chloro-7-methylquinazolin-2-yl)-3-fluorophenol

: 879275-42-0
2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol

Guidance literature:: With oxalic acid; triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 879275-42-0
2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol

: 76-05-1
trifluoroacetic acid

: (S)-tetrahydrofuran-3-yl ((S)-1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)piperidin-3-yl)methyl-carbamate trifluoroacetate

Guidance literature:: 2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol; (S)-tetrahydrofuran-3-yl carbonochloridate; With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 879275-42-0
2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol

: 76-05-1
trifluoroacetic acid

: isobutyl ((S)-1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)piperidin-3-yl)methylcarbamate trifluoroacetate

Guidance literature:: 2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol; isobutyl chloroformate; With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

trifluoroacetic acid; In water; acetonitrile;