tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate

Base Information

Chemical Name:tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate
CAS No.:117559-52-1
Molecular Formula:9C₂HF₃O₂*10C₂₉H₃₀N₆O₉
Molecular Weight:7092.14
Hs Code.:

tri-tert-butyl N-<N-<4-<N-<(2-amino-4-hydroxy-6-quinazolinyl)methyl>prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate

Synonyms:tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate

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Chemical Property of tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate

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Technology Process of tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate

There total 8 articles about tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 117559-48-5
tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate

: 76-05-1
trifluoroacetic acid

: 117559-52-1
tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate

Guidance literature:: for 1h; Ambient temperature;
DOI:10.1021/jm00121a029

Reference yield:

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 117559-52-1
tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

2: H₂ / 10percent Pd/C / methanol

3: 90 percent / N-methylmorpholine / dioxane / 0.33 h / Ambient temperature

4: H₂ / 10percent Pd/C / methanol / 1 h

5: 40 percent / 2,6-dimethylpyridine / dimethylformamide / 70 h / Ambient temperature

6: 71 percent / CaCO₃ / N,N-dimethyl-acetamide / 132 h / Ambient temperature

7: 86 percent / 1 h / Ambient temperature

With 4-methyl-morpholine; 2,6-dimethylpyridine; hydrogen; calcium carbonate; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00121a029

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 117559-52-1
tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

2: H₂ / 10percent Pd/C / methanol

3: 90 percent / N-methylmorpholine / dioxane / 0.33 h / Ambient temperature

4: H₂ / 10percent Pd/C / methanol / 1 h

5: 40 percent / 2,6-dimethylpyridine / dimethylformamide / 70 h / Ambient temperature

6: 71 percent / CaCO₃ / N,N-dimethyl-acetamide / 132 h / Ambient temperature

7: 86 percent / 1 h / Ambient temperature

With 4-methyl-morpholine; 2,6-dimethylpyridine; hydrogen; calcium carbonate; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00121a029