117559-48-5Relevant articles and documents
Quinazoline Antifolates Inhibiting Thymidylate Synthase: Synthesis of Four Oligo(L-γ-glutamyl) Conjugates of N10-Propargyl-5,8-dideazafolic Acid and Their Enzyme Inhibition
Pawelczak, Krzysztof,Jones, Terence R.,Kempny, Michal,Jackman, Ann L.,Newell, David R.,et al.
, p. 160 - 165 (2007/10/02)
The synthesis is described of four oligo(γ-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid containing a total of two, three, four, and five L-glutamic acid residues.The tert-butyl group was chosen as the carboxyl protecting group in