2-(2-chloro-5-(difluoromethoxy)phenyl)-3-(phenylacetoxy)propanenitrile

Base Information

Chemical Name:2-(2-chloro-5-(difluoromethoxy)phenyl)-3-(phenylacetoxy)propanenitrile
CAS No.:1034694-25-1
Molecular Formula:C₁₈H₁₄ClF₂NO₃
Molecular Weight:365.764
Hs Code.:

Synonyms:2-(2-chloro-5-(difluoromethoxy)phenyl)-3-(phenylacetoxy)propanenitrile

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Chemical Property of 2-(2-chloro-5-(difluoromethoxy)phenyl)-3-(phenylacetoxy)propanenitrile

Chemical Property:

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Technology Process of 2-(2-chloro-5-(difluoromethoxy)phenyl)-3-(phenylacetoxy)propanenitrile

There total 6 articles about 2-(2-chloro-5-(difluoromethoxy)phenyl)-3-(phenylacetoxy)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1555-80-2
phenylacetic anhydride

: 1034694-53-5
2-(2-chloro-5-(difluoromethoxy)phenyl)-3-hydroxypropanenitrile

: 1034694-25-1
2-(2-chloro-5-(difluoromethoxy)phenyl)-3-(phenylacetoxy)propanenitrile

Guidance literature:: sulfuric acid; In acetonitrile; at 75 ℃; for 0.5h;

Reference yield:

: 1017779-54-2
2-bromomethyl-1-chloro-4-(difluoromethoxy)benzene

: 1034694-25-1
2-(2-chloro-5-(difluoromethoxy)phenyl)-3-(phenylacetoxy)propanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C

2: N-benzyl-trimethylammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; ethanol / 0.83 h / 20 °C

3: sulfuric acid / acetonitrile / 0.5 h / 75 °C

With hydrogenchloride; N-benzyl-trimethylammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; sulfuric acid; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1034694-51-3
2-(2-chloro-5-(difluoromethoxy)phenyl)ethanenitrile

: 1034694-25-1
2-(2-chloro-5-(difluoromethoxy)phenyl)-3-(phenylacetoxy)propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-benzyl-trimethylammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; ethanol / 0.83 h / 20 °C

2: sulfuric acid / acetonitrile / 0.5 h / 75 °C

With N-benzyl-trimethylammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; sulfuric acid; In methanol; ethanol; acetonitrile;