Bis(benzeneacetic acid)anhydride

Base Information

• Chemical Name: Bis(benzeneacetic acid)anhydride
• CAS No.: 1555-80-2
• Molecular Formula: C16H14 O3
• Molecular Weight: 254.285
• Hs Code.: 2916399090
• Mol file: 1555-80-2.mol

Synonyms:Aceticacid, phenyl-, anhydride (6CI,7CI,8CI); Benzeneacetic acid, anhydride (9CI);NSC 243712; Phenylacetic acid anhydride; Phenylacetic anhydride; Phenylacetylanhydride

Chemical Property of Bis(benzeneacetic acid)anhydride

Chemical Property:

• Vapor Pressure: 3.07E-06mmHg at 25°C
• Melting Point: 73.3°C
• Refractive Index: 1.5600 (estimate)
• Boiling Point: 388.4°C at 760 mmHg
• Flash Point: 181°C
• PSA: 43.37000
• Density: 1.174g/cm³
• LogP: 2.54160

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bis(benzeneacetic acid)anhydride

There total 22 articles about Bis(benzeneacetic acid)anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phenylacetic acid (103-82-2) → phenylacetic anhydride (1555-80-2)

Guidance literature:

With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1055/s-1981-29544

Reference yield: 96.0%

phenylacetic acid (103-82-2) + potassium phenylacetate (13005-36-2) → phenylacetic anhydride (1555-80-2)

Guidance literature:

phenylacetic acid; With trichloroisocyanuric acid; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;

potassium phenylacetate; In dichloromethane; at 20 ℃; for 1.33333h;

DOI:10.1515/chempap-2015-0042

Reference yield: 66.0%

sodium phenylacetate (114-70-5) + phenylacetyl chloride (103-80-0) → phenylacetic anhydride (1555-80-2)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In dichloromethane; for 0.5h;

upstream raw materials:

4-methyleneoxetan-2-one

phenylacetic acid

acetic anhydride

3,4-dioxo-5-phenyl-valeronitrile

Downstream raw materials:

1-(furan-2-yl)-2-phenylethanone

(E)-2,3-diphenylpropenoic acid

p-tolyl phenylacetate

6-chloro-4-methyl-3-phenyl-coumarin

Refernces

• 1、 Gerrard,Thrush. "-". . p. 2117,2118, 2120. Retrieved 1953.
• 2、 Qu, Shen,Greenhalgh, Mark D.,Smith, Andrew D.. "Isothiourea-Catalysed Regioselective Acylative Kinetic Resolution of Axially Chiral Biaryl Diols". supporting information. p. 2816 - 2823. Retrieved 2019/02/05.
• 3、 -. "INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE". Page/Page column 113. . Retrieved 2019/03/05.