(S)-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((((2-tert-butoxy)carbonyl)oxy)-5-ethoxyphenylthio)phenyl}-2-propylbutan-1-ol

Base Information

Chemical Name:(S)-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((((2-tert-butoxy)carbonyl)oxy)-5-ethoxyphenylthio)phenyl}-2-propylbutan-1-ol
CAS No.:1383617-39-7
Molecular Formula:C₃₁H₄₄ClNO₇S
Molecular Weight:610.212
Hs Code.:

Synonyms:(S)-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((((2-tert-butoxy)carbonyl)oxy)-5-ethoxyphenylthio)phenyl}-2-propylbutan-1-ol

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Chemical Property of (S)-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((((2-tert-butoxy)carbonyl)oxy)-5-ethoxyphenylthio)phenyl}-2-propylbutan-1-ol

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Technology Process of (S)-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((((2-tert-butoxy)carbonyl)oxy)-5-ethoxyphenylthio)phenyl}-2-propylbutan-1-ol

There total 11 articles about (S)-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((((2-tert-butoxy)carbonyl)oxy)-5-ethoxyphenylthio)phenyl}-2-propylbutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383617-33-1
(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((2-((tert-butoxy)carbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}butan-1-ol

: 1383617-39-7
(S)-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((((2-tert-butoxy)carbonyl)oxy)-5-ethoxyphenylthio)phenyl}-2-propylbutan-1-ol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 15 - 25 ℃; for 10h; under 760.051 Torr;

Reference yield:

: 1260511-73-6
5-ethoxy-2-hydroxybenzenethiol

: 1383617-39-7
(S)-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((((2-tert-butoxy)carbonyl)oxy)-5-ethoxyphenylthio)phenyl}-2-propylbutan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 17 h / Inert atmosphere; Reflux

2: triethylamine / water; acetonitrile / 60 h / 15 - 25 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 10 h / 15 - 25 °C / 760.05 Torr

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; acetonitrile;

Reference yield:

: 1383617-32-0
(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((5-ethoxy-2-hydroxyphenyl)thio)phenyl}butan-1-ol

: 1383617-39-7
(S)-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((((2-tert-butoxy)carbonyl)oxy)-5-ethoxyphenylthio)phenyl}-2-propylbutan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / water; acetonitrile / 60 h / 15 - 25 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 10 h / 15 - 25 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; water; acetonitrile;