(R)-2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(((tert-butoxy)carbonyl)amino)-4-penten-1-ol

Base Information

Chemical Name:(R)-2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(((tert-butoxy)carbonyl)amino)-4-penten-1-ol
CAS No.:1260511-63-4
Molecular Formula:C₁₈H₂₅BrClNO₃
Molecular Weight:418.758
Hs Code.:

Synonyms:(R)-2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(((tert-butoxy)carbonyl)amino)-4-penten-1-ol

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Chemical Property of (R)-2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(((tert-butoxy)carbonyl)amino)-4-penten-1-ol

Chemical Property:

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Technology Process of (R)-2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(((tert-butoxy)carbonyl)amino)-4-penten-1-ol

There total 6 articles about (R)-2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(((tert-butoxy)carbonyl)amino)-4-penten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260511-61-2
methyl (R)-2-allyl-4-(4-bromo-2-chlorophenyl)-2-(((tert-butoxy)carbonyl)amino)butyrate

: 1260511-63-4
(R)-2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(((tert-butoxy)carbonyl)amino)-4-penten-1-ol

Guidance literature:: With lithium borohydride; ethanol; In tetrahydrofuran; for 2h; Cooling with ice;

Reference yield:

: C₁₄H₁₇BrClNO₂

: 1260511-63-4
(R)-2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(((tert-butoxy)carbonyl)amino)-4-penten-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 1 h / 15 - 25 °C

2: lithium borohydride; ethanol / tetrahydrofuran / 2 h / Cooling with ice

With lithium borohydride; ethanol; In tetrahydrofuran; acetonitrile;

Reference yield:

: 190079-30-2
(5R)-2-allyl-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine

: 1260511-63-4
(R)-2-[2-(4-bromo-2-chlorophenyl)ethyl]-2-(((tert-butoxy)carbonyl)amino)-4-penten-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / water / 1 h / 15 - 25 °C

3.1: acetonitrile / 1 h / 15 - 25 °C

4.1: lithium borohydride; ethanol / tetrahydrofuran / 2 h / Cooling with ice

With lithium borohydride; n-butyllithium; ethanol; trifluoroacetic acid; In tetrahydrofuran; hexane; water; acetonitrile;