methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate

Base Information

Chemical Name:methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate
CAS No.:288852-06-2
Molecular Formula:C₂₀H₂₃NO₆
Molecular Weight:373.406
Hs Code.:

Synonyms:methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate

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Chemical Property of methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate

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Technology Process of methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate

There total 1 articles about methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1676-81-9
N-benzyloxycarbonyl-L-serine methyl ester

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 288852-06-2
methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 1.25h;
DOI:10.1021/ol990320r

Reference yield: 88.0%

: 288852-06-2
methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate

: (R)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)amino-1-propanol

Guidance literature:: With lithium borohydride; In methanol; diethyl ether; for 0.25h; Heating;
DOI:10.1021/ol990320r

Reference yield:

: 288852-06-2
methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate

: 288852-11-9
methyl 2-((2S,3S)-2-benzoyloxy-4-(4-methoxyphenyl)methoxy-3-(N-phenylmethoxycarbonyl)amino)butylpropenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / LiBH₄ / methanol; diethyl ether / 0.25 h / Heating

2: 93 percent / Dess-Martin periodinane / CH₂Cl₂ / 3 h / 20 °C

3: 37 percent / indium / tetrahydrofuran; H₂O / 4.5 h

4: 64 percent / di-tert-butyl azodicarboxylate; Ph₃P / tetrahydrofuran / 20 °C

With indium; lithium borohydride; di-tert-butyl-diazodicarboxylate; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 1: Reduction / 2: Oxidation / 3: Condensation / 4: Mitsunobu reaction;
DOI:10.1021/ol990320r