5-(1H-benzo[d]imidazol-2-yl)-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 5-(1H-benzo[d]imidazol-2-yl)-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• CAS No.: 1354943-54-6
• Molecular Formula: C₁₆H₁₆N₄O₅
• Molecular Weight: 344.327
• Mol file: 1354943-54-6.mol

Synonyms:5-(1H-benzo[d]imidazol-2-yl)-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Chemical Property of 5-(1H-benzo[d]imidazol-2-yl)-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-(1H-benzo[d]imidazol-2-yl)-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

There total 1 articles about 5-(1H-benzo[d]imidazol-2-yl)-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1,2-diamino-benzene (95-54-5) + 5-formyl-2'-deoxyuridine (4494-26-2) → 5-(1H-benzo[d]imidazol-2-yl)-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (1354943-54-6)

Guidance literature:

In water; dimethyl sulfoxide; at 20 ℃; for 24h; Irradiation;

DOI:10.1002/adsc.201901032

Reference yield: 58.0%

5-(1H-benzo[d]imidazol-2-yl)-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (1354943-54-6) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 5-(1H-benzo[d]imidazol-2-yl)-1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-β-D-erythropentofuranosyl]uracil

Guidance literature:

With pyridine; at 20 ℃; for 4h;

DOI:10.1039/c6ob02560a

Reference yield:

5-(1H-benzo[d]imidazol-2-yl)-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (1354943-54-6) → C46H51N6O8P

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1039/c6ob02560a

upstream raw materials:

1,2-diamino-benzene

5-formyl-2'-deoxyuridine