3,4-difluorocinnamyl alcohol

Base Information

• Chemical Name: 3,4-difluorocinnamyl alcohol
• CAS No.: 376584-18-8
• Molecular Formula: C₉H₈F₂O
• Molecular Weight: 170.159
• Mol file: 376584-18-8.mol

Synonyms:3,4-difluorocinnamyl alcohol

Chemical Property of 3,4-difluorocinnamyl alcohol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-difluorocinnamyl alcohol

There total 4 articles about 3,4-difluorocinnamyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4-difluorobenzeneprop-2-ynol (893747-16-5) → 3,4-difluorocinnamyl alcohol (376584-18-8)

Guidance literature:

With 5% Pd-CaCO3; hydrogen; at 50 ℃; for 24h;

Reference yield:

ethyl 3-(3,4-difluorophenyl)acrylate (375368-92-6) → 3,4-difluorocinnamyl alcohol (376584-18-8)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -20 ℃;

DOI:10.3390/molecules16053580

Reference yield:

3,4 difluorobenzaldehyde (34036-07-2) → 3,4-difluorocinnamyl alcohol (376584-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 4 h / 80 °C

2: diisobutylaluminium hydride / dichloromethane / -20 °C

With diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.3390/molecules16053580

upstream raw materials:

3,4 difluorobenzaldehyde

ethyl 3-(3,4-difluorophenyl)acrylate

1,2-difluoro-4-iodo-benzene

3,4-difluorobenzeneprop-2-ynol