(R)-N-(2,3-dihydroxypropyl)stearamide

Base Information

• Chemical Name: (R)-N-(2,3-dihydroxypropyl)stearamide
• CAS No.: 955998-69-3
• Molecular Formula: C₂₁H₄₃NO₃
• Molecular Weight: 357.577
• Mol file: 955998-69-3.mol

Synonyms:(R)-N-(2,3-dihydroxypropyl)stearamide

Chemical Property of (R)-N-(2,3-dihydroxypropyl)stearamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(2,3-dihydroxypropyl)stearamide

There total 1 articles about (R)-N-(2,3-dihydroxypropyl)stearamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R)-3-amino-1,2-propanediol (66211-46-9,98923-21-8) + Stearoyl chloride (112-76-5) → (R)-N-(2,3-dihydroxypropyl)stearamide (955998-69-3,7336-25-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; methanol; at 0 - 20 ℃;

DOI:10.1021/acschemneuro.8b00505

Reference yield: 83.0%

(R)-N-(2,3-dihydroxypropyl)stearamide (955998-69-3,7336-25-6) + mono-4-methoxytrityl chloride (14470-28-1) → C41H59NO4 (955948-50-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 50 ℃; for 2h;

DOI:10.1021/jm900598m

Reference yield:

(R)-N-(2,3-dihydroxypropyl)stearamide (955998-69-3,7336-25-6) → 3-(2-O-benzoyl-1-N-stearamido-sn-glycerol) (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl) phosphate triethylammonium salt

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / 20 °C / Inert atmosphere; Heating

2.1: dmap / pyridine / 1.5 h / 20 - 80 °C / Inert atmosphere; Schlenk technique

3.1: Amberlyst IR-120 ion-exchange resin / dichloromethane / 2 h / 20 °C

4.1: pivaloyl chloride; pyridine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Schlenk technique

4.2: 0.5 h / 20 °C

With pyridine; dmap; pivaloyl chloride; In tetrahydrofuran; pyridine; dichloromethane;

DOI:10.1021/acschemneuro.8b00505

upstream raw materials:

(R)-3-amino-1,2-propanediol

Stearoyl chloride

Downstream raw materials:

C₄₁H₅₉NO₄