(3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Base Information

Chemical Name:(3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
CAS No.:450416-64-5
Molecular Formula:C₂₀H₂₁NO₃
Molecular Weight:323.392
Hs Code.:

Synonyms:(3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Chemical Property of (3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Technology Process of (3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

There total 3 articles about (3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 20989-17-7
(2S)-2-phenylglycinol

: 450416-61-2
methyl 4-(3-methoxyphenyl)-5-oxopentanoate

: 450416-65-6
(3S,8R,8aR)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 450416-64-5
(3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: In toluene; for 24h; Heating;
DOI:10.1021/jo025894f

Reference yield:

: 65292-99-1
2-(3-methoxyphenyl)acetaldehyde

: 450416-64-5
(3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Na₂CO₃; 4 Angstroem molecular sieves / 2 h / 0 °C

2.1: 4 Angstroem molecular sieves / ethanol / 14 h / 80 °C

2.2: 37 percent / acetic acid; water / ethanol / 3 h / 80 °C

3.1: 59 percent / toluene / 24 h / Heating

With 4 A molecular sieve; sodium carbonate; In ethanol; toluene;
DOI:10.1021/jo025894f

Reference yield:

: 450416-60-1
1-[(E)-2-(3-Methoxy-phenyl)-vinyl]-pyrrolidine

: 450416-64-5
(3S,8S,8aS)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4 Angstroem molecular sieves / ethanol / 14 h / 80 °C

1.2: 37 percent / acetic acid; water / ethanol / 3 h / 80 °C

2.1: 59 percent / toluene / 24 h / Heating

With 4 A molecular sieve; In ethanol; toluene;
DOI:10.1021/jo025894f