cis-2,6-bis-(tert-butyldimethylsilanyloxymethyl)-2,6-diethyl-1-(1-phenylethoxy)-piperidine

Base Information

Chemical Name:cis-2,6-bis-(tert-butyldimethylsilanyloxymethyl)-2,6-diethyl-1-(1-phenylethoxy)-piperidine
CAS No.:651352-17-9
Molecular Formula:C₃₁H₅₉NO₃Si₂
Molecular Weight:549.985
Hs Code.:

Synonyms:cis-2,6-bis-(tert-butyldimethylsilanyloxymethyl)-2,6-diethyl-1-(1-phenylethoxy)-piperidine

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Chemical Property of cis-2,6-bis-(tert-butyldimethylsilanyloxymethyl)-2,6-diethyl-1-(1-phenylethoxy)-piperidine

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Technology Process of cis-2,6-bis-(tert-butyldimethylsilanyloxymethyl)-2,6-diethyl-1-(1-phenylethoxy)-piperidine

There total 6 articles about cis-2,6-bis-(tert-butyldimethylsilanyloxymethyl)-2,6-diethyl-1-(1-phenylethoxy)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 651352-11-3
cis-2,6-bis-hydroxymethyl-2,6-diethyl-1-(1-phenylethoxy)piperidine

: 651352-17-9
cis-2,6-bis-(tert-butyldimethylsilanyloxymethyl)-2,6-diethyl-1-(1-phenylethoxy)-piperidine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/ja037948o

Reference yield:

: 651351-95-0
cis-2,6-diethylpiperidine-2,6-dicarboxylic acid dimethyl ester-1-oxyl radical

: 651352-17-9
cis-2,6-bis-(tert-butyldimethylsilanyloxymethyl)-2,6-diethyl-1-(1-phenylethoxy)-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.167 g / Cu(OTf)2; 4,4'-di-tert-butyl-2,2-bipyridine; Cu / benzene / 18 h / 75 °C

2: 66 percent / lithium aluminum hydride / tetrahydrofuran / 39 h / 25 °C

3: 86 percent / imidazole / dimethylformamide / 3 h

With 1H-imidazole; lithium aluminium tetrahydride; copper(II) bis(trifluoromethanesulfonate); copper; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja037948o

Reference yield:

: 651352-49-7
cis-2,6-diethylpiperidine-2,6-dicarboxylic acid dimethyl ester

: 651352-17-9
cis-2,6-bis-(tert-butyldimethylsilanyloxymethyl)-2,6-diethyl-1-(1-phenylethoxy)-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: Na₂WO₄; aq. H₂O₂ / methanol / 15 h / 20 °C

2: 1.167 g / Cu(OTf)2; 4,4'-di-tert-butyl-2,2-bipyridine; Cu / benzene / 18 h / 75 °C

3: 66 percent / lithium aluminum hydride / tetrahydrofuran / 39 h / 25 °C

4: 86 percent / imidazole / dimethylformamide / 3 h

With 1H-imidazole; sodium tungstate; lithium aluminium tetrahydride; dihydrogen peroxide; copper(II) bis(trifluoromethanesulfonate); copper; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja037948o