9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

Base Information

Chemical Name:9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate
CAS No.:1596360-83-6
Molecular Formula:C₃₉H₃₇FN₈O₄
Molecular Weight:700.772
Hs Code.:

9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

Synonyms:9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

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Chemical Property of 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

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Technology Process of 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

There total 10 articles about 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1596360-12-1
5-bromo-4-methylamino-pyrimidine-2-carbonitrile

: 1596360-83-6
9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride / 15 h / 20 °C

2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 4 h / 80 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 - 100 °C

4: hydrogenchloride; sodium hydrogencarbonate / methanol / 3 h / 20 °C

5: carbon tetrabromide; triphenylphosphine / dichloromethane / 3.5 h / 0 - 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

7: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 3 h / 20 °C

8: triethylamine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; carbon tetrabromide; water; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.02.002

Reference yield:

: 1523354-68-8
methyl 5-bromo-4-methylamino-pyrimidine-2-carboxylate

: 1596360-83-6
9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 4 h / 80 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 - 100 °C

3: hydrogenchloride; sodium hydrogencarbonate / methanol / 3 h / 20 °C

4: carbon tetrabromide; triphenylphosphine / dichloromethane / 3.5 h / 0 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

6: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 3 h / 20 °C

7: triethylamine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; carbon tetrabromide; water; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.02.002

Reference yield:

: 13908-32-2
1-(2-chloroethyl)-3-(4-fluorophenyl)urea

: 1596360-83-6
9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 15 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

3: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 3 h / 20 °C

4: triethylamine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 °C

With 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; water; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.02.002