(11β,17α)-9-fluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-{[3-(methylthio)phenyl]thio}benzoate

Base Information

Chemical Name:(11β,17α)-9-fluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-{[3-(methylthio)phenyl]thio}benzoate
CAS No.:1257086-12-6
Molecular Formula:C₃₅H₃₆F₂O₅S₃
Molecular Weight:670.863
Hs Code.:

Synonyms:(11β,17α)-9-fluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-{[3-(methylthio)phenyl]thio}benzoate

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Chemical Property of (11β,17α)-9-fluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-{[3-(methylthio)phenyl]thio}benzoate

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Technology Process of (11β,17α)-9-fluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-{[3-(methylthio)phenyl]thio}benzoate

There total 3 articles about (11β,17α)-9-fluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-{[3-(methylthio)phenyl]thio}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 373-52-4
bromofluoromethane

: 1257087-13-0
4-{[3-(methylthio)phenyl]thio}benzoic acid

: 80473-91-2
9α-fluoro-11β,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carbothioic acid

: 1257086-12-6
(11β,17α)-9-fluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-{[3-(methylthio)phenyl]thio}benzoate

Guidance literature:: 4-{[3-(methylthio)phenyl]thio}benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

9α-fluoro-11β,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carbothioic acid; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

bromofluoromethane;

Reference yield:

: 65144-65-2
3-(methylthio)benzenethiol

: 1257086-12-6
(11β,17α)-9-fluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-{[3-(methylthio)phenyl]thio}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: [2,2]bipyridinyl / copper(l) iodide / water; dimethyl sulfoxide / 16 h / 100 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; 1,4-dioxane / 1.5 h / 60 °C

2.2: 0 °C / pH 5.5

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 18 h / 20 °C

With [2,2]bipyridinyl; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1257086-12-6
(11β,17α)-9-fluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-3-oxoandrosta-1,4-dien-17-yl 4-{[3-(methylthio)phenyl]thio}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: [2,2]bipyridinyl / copper(l) iodide / water; dimethyl sulfoxide / 16 h / 100 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; 1,4-dioxane / 1.5 h / 60 °C

2.2: 0 °C / pH 5.5

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 18 h / 20 °C

With [2,2]bipyridinyl; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;