Multi-step reaction with 10 steps
1.1: thionyl chloride / benzene / 3.5 h / 75 °C
2.1: ammonia / tetrahydrofuran / 12 h / 0 - 20 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol; 1,2-dimethoxyethane / 16 h / 20 °C
4.1: pyridine / chloroform / 18 h / 20 - 55 °C
5.1: sodium hydroxide / water / 5 h / 105 °C
5.2: 20 °C
6.1: methanesulfonic acid; DL-methionine / 5.5 h / 110 °C
7.1: pyridine / 4 h / 105 °C
8.1: thionyl chloride; N,N-dimethyl-formamide / 5 h / Heating / reflux
8.2: 20 °C
9.1: isopropyl alcohol / 5 h / 95 °C
10.1: methanol; ammonia; water / 24 h / 20 °C
With
pyridine; methanol; sodium hydroxide; thionyl chloride; methanesulfonic acid; ammonia; water; hydrogen; N,N-dimethyl-formamide; DL-methionine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; water; isopropyl alcohol; benzene;