tert-butyl 5-(6-acetoxy-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Chemical Name:tert-butyl 5-(6-acetoxy-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate
CAS No.:911418-03-6
Molecular Formula:C₃₅H₃₀FN₅O₅
Molecular Weight:619.652
Hs Code.:

Synonyms:tert-butyl 5-(6-acetoxy-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl 5-(6-acetoxy-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Technology Process of tert-butyl 5-(6-acetoxy-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

There total 7 articles about tert-butyl 5-(6-acetoxy-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 129488-10-4
5-Amino-indazole-1-carboxylic acid tert-butyl ester

: 911418-02-5
4-chloro-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-6-yl acetate

: 911418-03-6
tert-butyl 5-(6-acetoxy-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: In isopropyl alcohol; at 95 ℃; for 5h;

Reference yield:

: 4998-07-6
4,5-dimethoxy-2-nitro-benzoic acid

: 911418-03-6
tert-butyl 5-(6-acetoxy-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: thionyl chloride / benzene / 3.5 h / 75 °C

2.1: ammonia / tetrahydrofuran / 12 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol; 1,2-dimethoxyethane / 16 h / 20 °C

4.1: pyridine / chloroform / 18 h / 20 - 55 °C

5.1: sodium hydroxide / water / 5 h / 105 °C

5.2: 20 °C

6.1: methanesulfonic acid; DL-methionine / 5.5 h / 110 °C

7.1: pyridine / 4 h / 105 °C

8.1: thionyl chloride; N,N-dimethyl-formamide / 5 h / Heating / reflux

8.2: 20 °C

9.1: isopropyl alcohol / 5 h / 95 °C

With pyridine; sodium hydroxide; thionyl chloride; methanesulfonic acid; ammonia; hydrogen; N,N-dimethyl-formamide; DL-methionine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; water; isopropyl alcohol; benzene;

Reference yield:

: 4959-60-8
4,5-dimethoxy-2-nitrobenzamide

: 911418-03-6
tert-butyl 5-(6-acetoxy-2-(3-fluoro-4-(phenyl)phenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol; 1,2-dimethoxyethane / 16 h / 20 °C

2.1: pyridine / chloroform / 18 h / 20 - 55 °C

3.1: sodium hydroxide / water / 5 h / 105 °C

3.2: 20 °C

4.1: methanesulfonic acid; DL-methionine / 5.5 h / 110 °C

5.1: pyridine / 4 h / 105 °C

6.1: thionyl chloride; N,N-dimethyl-formamide / 5 h / Heating / reflux

6.2: 20 °C

7.1: isopropyl alcohol / 5 h / 95 °C

With pyridine; sodium hydroxide; thionyl chloride; methanesulfonic acid; hydrogen; N,N-dimethyl-formamide; DL-methionine; palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; chloroform; water; isopropyl alcohol;