nicotinic acid 4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl ester

Base Information

Chemical Name:nicotinic acid 4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl ester
CAS No.:1187948-77-1
Molecular Formula:C₂₂H₂₆N₂O₃
Molecular Weight:366.46
Hs Code.:

Synonyms:nicotinic acid 4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl ester

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Chemical Property of nicotinic acid 4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl ester

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Technology Process of nicotinic acid 4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl ester

There total 7 articles about nicotinic acid 4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 59-67-6
nicotinic acid

: 1187948-72-6
4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol

: 1187948-77-1
nicotinic acid 4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1187948-66-8
7-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1,2,3,4-tetrahydro-isoquinoline

: 1187948-77-1
nicotinic acid 4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec.-butyllithium / toluene / 2 h / -78 °C

1.2: 19 h / -78 - 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

3.1: dmap; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 16 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; sec.-butyllithium; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1187948-63-5
7-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3,4-dihydro-2H-isoquinolin-1-one

: 1187948-77-1
nicotinic acid 4-(1-hydroxy-cyclohexyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

2.1: sec.-butyllithium / toluene / 2 h / -78 °C

2.2: 19 h / -78 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

4.1: dmap; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 16 h / 20 °C

With dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sec.-butyllithium; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;