(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(trifluoromethyl)phenyl)boronic acid

Base Information

Chemical Name:(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(trifluoromethyl)phenyl)boronic acid
CAS No.:1423007-63-9
Molecular Formula:C₂₇H₂₃BF₄N₂O₆S
Molecular Weight:590.36
Hs Code.:

Synonyms:(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(trifluoromethyl)phenyl)boronic acid

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Chemical Property of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(trifluoromethyl)phenyl)boronic acid

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Technology Process of (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(trifluoromethyl)phenyl)boronic acid

There total 18 articles about (4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(trifluoromethyl)phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1423007-66-2
6-{N-[4-bromo-3-(trifluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

: 73183-34-3
bis(pinacol)diborane

: 1423007-63-9
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(trifluoromethyl)phenyl)boronic acid

Guidance literature:: 6-{N-[4-bromo-3-(trifluoromethyl)phenyl]methanesulfonamido}-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide; bis(pinacol)diborane; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; sodium periodate; In tetrahydrofuran; water; for 3h;

Reference yield:

: C₃₃H₃₃BF₄N₂O₆S

: 1423007-63-9
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(trifluoromethyl)phenyl)boronic acid

Guidance literature:: With hydrogenchloride; sodium periodate; water; In tetrahydrofuran; water; for 3h;

Reference yield:

: 1423007-64-0
5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-{N-[4-nitro-3-(trifluoromethyl)phenyl]methanesulfonamido}-1-benzofuran-3-carboxamide

: 1423007-63-9
(4-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-(trifluoromethyl)phenyl)boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogenchloride / methanol / 1 h / 517.16 Torr

2.1: hydrogen bromide; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C

2.2: 1 h / 60 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

3.2: 3 h

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen bromide; potassium acetate; sodium nitrite; In 1,4-dioxane; methanol; water; acetonitrile; 2.1: |Sandmeyer Reaction;