(R)-N-ethyl-N-(6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

Base Information

Chemical Name:(R)-N-ethyl-N-(6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide
CAS No.:1589539-57-0
Molecular Formula:C₁₉H₂₂N₆O₂
Molecular Weight:366.423
Hs Code.:

Synonyms:(R)-N-ethyl-N-(6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

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Chemical Property of (R)-N-ethyl-N-(6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

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Technology Process of (R)-N-ethyl-N-(6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

There total 4 articles about (R)-N-ethyl-N-(6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1589540-87-3
(R)-1-(3-(ethylamino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea

: 75-36-5
acetyl chloride

: 1589539-57-0
(R)-N-ethyl-N-(6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

Guidance literature:: (R)-1-(3-(ethylamino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea; acetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With triethylamine; In dichloromethane; for 0.25h;

Reference yield:

: 6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridine

: 1589539-57-0
(R)-N-ethyl-N-(6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: rac-Pro-OH; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 24 h / 70 °C

2.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate / tetrahydrofuran / 6 h / 20 - 50 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

3.2: 1 h / 20 °C

3.3: 0.25 h

With copper(l) iodide; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); potassium carbonate; N-ethyl-N,N-diisopropylamine; rac-Pro-OH; sodium t-butanolate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1589540-86-2
6-chloro-N-ethyl-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-amine

: 1589539-57-0
(R)-N-ethyl-N-(6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate / tetrahydrofuran / 6 h / 20 - 50 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

2.2: 1 h / 20 °C

2.3: 0.25 h

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In tetrahydrofuran; dichloromethane;