4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel

Base Information

• Chemical Name: 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel
• CAS No.: 817208-01-8
• Molecular Formula: C₇₂H₉₅NO₁₇Si₂
• Molecular Weight: 1302.71

Synonyms:4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel

Chemical Property of 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel

Chemical Property:

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Technology Process of 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel

There total 1 articles about 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-deacetyl-4-(5-hexenoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel (817207-99-1) → 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel (817208-01-8)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2004.09.002

Reference yield:

4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel (817208-01-8) → 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel (817207-65-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2004.09.002

upstream raw materials:

4-deacetyl-4-(5-hexenoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel

Downstream raw materials:

4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel

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