4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel

Base Information

Chemical Name:4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel
CAS No.:817207-65-1
Molecular Formula:C₆₅H₈₉NO₁₇Si₂
Molecular Weight:1212.59
Hs Code.:

Synonyms:4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel

Chemical Property:

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Technology Process of 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel

There total 1 articles about 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 817208-01-8
4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-benzyloxyphenyl)-7-TES-2'-TIPS-paclitaxel

: 817207-65-1
4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2004.09.002

Reference yield:

: 817207-65-1
4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel

: 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)paclitaxel

Guidance literature:: With pyridine; hydrogen fluoride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2004.09.002

Reference yield:

: 817207-65-1
4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel

: 817208-06-3
C₆₅H₈₇NO₁₆Si₂

Guidance literature:: 4-deacetyl-4-(4-carboxybutanoyl)-3'-desphenyl-3'-(m-hydroxyphenyl)-7-TES-2'-TIPS-paclitaxel; With 2,4,6-trichlorobenzoyl chloride; In dichloromethane; at 20 ℃; for 0.5h;

With dmap; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2004.09.002