9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Base Information

• Chemical Name: 9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one
• CAS No.: 573714-62-2
• Molecular Formula: C₂₂H₂₂N₄O₃
• Molecular Weight: 390.442
• Mol file: 573714-62-2.mol

Synonyms:9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Chemical Property of 9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

There total 4 articles about 9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(ethylamino)-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide (1027299-36-0) → 9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one (573714-62-2)

Guidance literature:

With pyridine; sodium hexamethyldisilazane; at 90 ℃;

DOI:10.1021/jm00024a011

Reference yield:

2-Chloronicotinoyl chloride (49609-84-9) → 9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one (573714-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / i-PrNEt₂ / ethyl acetate / 0 °C

2: 94 percent / 110 °C

3: 77 percent / NaHMDS, pyridine / 90 °C

With pyridine; N,N-diethyl-N-isopropylamine; sodium hexamethyldisilazane; In ethyl acetate;

DOI:10.1021/jm00024a011

Reference yield:

4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester (162709-27-5) → 9-Benzyloxymethyl-5-ethyl-7-methoxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one (573714-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl / ethyl acetate

2: 47 percent / i-PrNEt₂ / ethyl acetate / 0 °C

3: 94 percent / 110 °C

4: 77 percent / NaHMDS, pyridine / 90 °C

With pyridine; hydrogenchloride; N,N-diethyl-N-isopropylamine; sodium hexamethyldisilazane; In ethyl acetate;

DOI:10.1021/jm00024a011

upstream raw materials:

2-(ethylamino)-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide

2-Chloronicotinoyl chloride

4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester

3-amino-4-<(benzyloxy)methyl>-2,6-dimethoxypyridine

Downstream raw materials:

Trifluoro-methanesulfonic acid 9-benzyloxymethyl-5-ethyl-11-oxo-10,11-dihydro-5H-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-7-yl ester

9-Benzyloxymethyl-5-ethyl-7-hydroxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one