1-{(4S,5R)-5-[4-(6-ethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Base Information

Chemical Name:1-{(4S,5R)-5-[4-(6-ethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone
CAS No.:1454907-12-0
Molecular Formula:C₂₂H₂₆F₃N₃O₂
Molecular Weight:421.463
Hs Code.:

Synonyms:1-{(4S,5R)-5-[4-(6-ethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

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Chemical Property of 1-{(4S,5R)-5-[4-(6-ethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

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Technology Process of 1-{(4S,5R)-5-[4-(6-ethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

There total 6 articles about 1-{(4S,5R)-5-[4-(6-ethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454907-08-4
methanesulfonic acid 5-{4-[(4S,5R)-3-(2,2-difluoroacetyl)-4-fluoromethyl-2,2-dimethyloxazolidin-5-yl]phenyl}pyridin-2-ylmethyl ester

: 75-04-7,85404-22-4
ethylamine

: 1454907-12-0
1-{(4S,5R)-5-[4-(6-ethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1454906-87-6
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazolidin-3-yl)ethanone

: 1454907-12-0
1-{(4S,5R)-5-[4-(6-ethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 6 h / 90 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 °C

3: tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1454907-07-3
2,2-difluoro-1-{(4S,5R)-4-fluoromethyl-5-[4-(6-hydroxymethylpyridin-3-yl)phenyl]-2,2-dimethyloxazolidin-3-yl}ethanone

: 1454907-12-0
1-{(4S,5R)-5-[4-(6-ethylaminomethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: tetrahydrofuran / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;