methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester

Base Information

• Chemical Name: methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester
• CAS No.: 1308380-36-0
• Molecular Formula: C₁₅H₂₃NO₆S
• Molecular Weight: 345.417

Synonyms:methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester

Chemical Property of methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester

There total 1 articles about methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanesulfonyl chloride (124-63-0) + [(R)-2-hydroxy-1-(2-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester → methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester (1308380-36-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;

DOI:10.1021/acs.jmedchem.6b01071

Reference yield: 42.0%

methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester (1308380-36-0) + 1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione (1308378-32-6) → [(R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-1-(2-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (1308380-37-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 12h; Inert atmosphere;

Reference yield:

methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester (1308380-36-0) + 1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione (1308378-34-8) → C37H40F7N5O6

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

DOI:10.1016/j.ejmech.2017.12.095

upstream raw materials:

methanesulfonyl chloride

Downstream raw materials:

3-[(R)-2-amino-2-(2-methoxy-phenyl)-ethyl]-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-1H-pyrimidine-2,4-dione

[(R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-1-(2-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

3-[(R)-2-amino-2-(2-hydroxy-phenyl)-ethyl]-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-1H-pyrimidine-2,4-dione

(R)-2-(2-(1-amino-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-5-(4-(3-nitrobenzyl)piperazin-1-yl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl)phenoxy)acetic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1308380-36-0 methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send