3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidine

Base Information

• Chemical Name: 3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidine
• CAS No.: 83985-99-3
• Molecular Formula: C₂₀H₂₃NOS
• Molecular Weight: 325.475
• Mol file: 83985-99-3.mol

Synonyms:6-(1-Methyl-3-piperidylmethyl)-6H-dibenz-1,4-oxathiepin

Chemical Property of 3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidine

There total 5 articles about 3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol (83193-50-4) → 1-<2-(2-hydroxyphenylthio)phenyl>-2-(1-methyl-3-piperidyl)ethene (83193-55-9) + 6-(1-Methyl-3-piperidylmethyl)-6H-dibenz-1,4-oxathiepin (83985-99-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 70 ℃;

DOI:10.1135/cccc19821367

Reference yield:

3-(chloromethyl)-1-methylpiperidine (52694-50-5) → 6-(1-Methyl-3-piperidylmethyl)-6H-dibenz-1,4-oxathiepin (83985-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Mg / tetrahydrofuran, reflux 3 h

2: 85 percent / NaH / dimethylformamide / 70 °C

With sodium hydride; magnesium; In N,N-dimethyl-formamide;

DOI:10.1135/cccc19821367

Reference yield:

2-fluorothiophenol (2557-78-0) → 6-(1-Methyl-3-piperidylmethyl)-6H-dibenz-1,4-oxathiepin (83985-99-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / aq. NaOH / hexamethylphosphoric acid triamide / 3.5 h / 100 °C

2: Mg / tetrahydrofuran, reflux 3 h

3: 85 percent / NaH / dimethylformamide / 70 °C

With sodium hydroxide; sodium hydride; magnesium; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;

DOI:10.1135/cccc19821367

upstream raw materials:

α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol

3-(chloromethyl)-1-methylpiperidine

2-fluorothiophenol

2-chloro-benzaldehyde