[5-(4-cyclopropylphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone

Base Information

Chemical Name:[5-(4-cyclopropylphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone
CAS No.:1076205-27-0
Molecular Formula:C₂₉H₂₅F₆N₅O
Molecular Weight:573.541
Hs Code.:

Synonyms:[5-(4-cyclopropylphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone

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Chemical Property of [5-(4-cyclopropylphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone

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Technology Process of [5-(4-cyclopropylphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone

There total 4 articles about [5-(4-cyclopropylphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076195-16-8
1-(4-cyclopropylphenyl)-4,4,4-trifluoro-2-methyl-1,3-butanedione

: (3-amino-1H-pyrazol-4-yl)[4-[(2,3,5-trimethylphenyl)methyl]-1-piperazinyl]methanone

: 1076205-27-0
[5-(4-cyclopropylphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone

Guidance literature:: With acetic acid; at 80 - 95 ℃; for 24h;

Reference yield:

: 1076205-98-5
4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester

: 1076205-27-0
[5-(4-cyclopropylphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; ethanol; water / 1 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 - 80 °C

3: acetic acid / 24 h / 80 - 95 °C

With hydrogenchloride; ethanol; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

Reference yield:

: 1-[(2,3,5-trifluorophenyl)methyl]piperazine dihydrochloride

: 1076205-27-0
[5-(4-cyclopropylphenyl)-6-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 - 80 °C

2: acetic acid / 24 h / 80 - 95 °C

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;