4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester
CAS No.:1076205-98-5
Molecular Formula:C₁₆H₂₁F₃N₂O₂
Molecular Weight:330.35
Hs Code.:

Synonyms:4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester

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Chemical Property of 4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester

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Technology Process of 4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester

There total 1 articles about 4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 126202-23-1
2,3,5-trifluorobenzaldehyde

: 1076205-98-5
4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: 1-t-Butoxycarbonylpiperazine; 2,3,5-trifluorobenzaldehyde; With acetic acid; In 1,1-dichloroethane; at 20 ℃; for 2h;

With sodium tris(acetoxy)borohydride; In 1,1-dichloroethane; at 20 ℃;

With water; sodium hydrogencarbonate; In 1,1-dichloroethane;

Reference yield:

: 1076205-98-5
4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester

: 1-[(2,3,5-trifluorophenyl)methyl]piperazine dihydrochloride

Guidance literature:: With hydrogenchloride; ethanol; water; at 20 ℃; for 1h;

Reference yield:

: 1076205-98-5
4-[(2,3,5-trifluorophenyl)methyl]piperazine-1-carboxylic acid 1,1-dimethylethyl ester

: 1076205-81-6
[5-(4-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl][4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinyl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; ethanol; water / 1 h / 20 °C

2: triethylamine / dichloromethane / 2 - 4 h / 0 - 20 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2.03 - 2.05 h / Heating / reflux

With hydrogenchloride; ethanol; water; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane;