FRAX1036

Base Information

Chemical Name:FRAX1036
CAS No.:1432908-05-8
Molecular Formula:C₂₈H₃₂ClN₇O
Molecular Weight:518.061
Hs Code.:
Mol file:1432908-05-8.mol

Synonyms:6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Suppliers and Price of FRAX1036

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
FRAX1036 >98%
1 g
$ 2200.00

DC Chemicals
FRAX1036 >98%
100 mg
$ 550.00

Crysdot
FRAX1036 98+%
100mg
$ 548.00

Crysdot
FRAX1036 98+%
25mg
$ 223.00

Crysdot
FRAX1036 98+%
50mg
$ 379.00

ChemScene
FRAX1036 99.32%
50mg
$ 450.00

ChemScene
FRAX1036 99.32%
1mg
$ 60.00

ChemScene
FRAX1036 99.32%
5mg
$ 110.00

ChemScene
FRAX1036 99.32%
10mg
$ 150.00

Cayman Chemical
FRAX1036 ≥98%
5mg
$ 167.00

Total 11 raw suppliers

Chemical Property of FRAX1036

Chemical Property:

Solubility.:Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

FRAX1036 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description FRAX1036 is a selective inhibitor of p21-activated kinase 1 (PAK1), a serine/threonine kinase downstream of Rac1 and Cdc42 that is involved in tumorigenesis. It can induce apoptosis in breast cancer cells and has been shown to potentiate the activity of the microtubule stabilizing agent, docetaxel . Disruption of PAK1 via FRAX1036 has been used to inhibit oncogenic KRAS signaling in non-small cell lung cancer cells.

Technology Process of FRAX1036

There total 13 articles about FRAX1036 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1433193-87-3
2-chloro-6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethylpyrido[2,3-d]pyrimidin-7(8H)-one

: 20845-38-9
<2-(1-methyl-4-piperidyl)ethyl>amine

: 1432908-05-8
6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: In N,N-dimethyl-formamide; at 85 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.tetlet.2015.12.059

Reference yield:

: 849934-94-7
methyl 2-(4-bromo-2-chlorophenyl)acetate

: 1432908-05-8
6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water; toluene / 100 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 20 °C / Inert atmosphere

4: N,N-dimethyl-formamide / 48 h / 85 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2015.12.059

Reference yield:

: 849934-95-8
methyl 2-(2-chloro-4-(1,1,2,2-tetramethyl-1λ4,2λ4,4-dioxaborolan-4-yl)phenyl)acetate

: 1432908-05-8
6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water; toluene / 100 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 20 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 48 h / 85 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2015.12.059